Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 651734-54-2, name is 2,6-Difluoro-3,5-dimethoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C8H9F2NO2
TEA (0.15mL) was added to a solution of 6-chloro nicotinic acid (0.12g, 0.79 mmol) in DMF (2mL) followed by the addition of T3P (0.67mg, 1.0 mmol). Stirred the reaction mass for 10 min. and added 2,6-difluoro-3,5-dimethoxyaniline (O. lg, 0.52mmol). Continued the stirring with heating at 100 C for 24h. Quenched the reaction mass with ice cold water and the solid separated is filtered, dried under vacuum to afford desired title compound (0.14g, 80%). LCMS: m/z = 329.0 (M+H)+.
According to the analysis of related databases, 651734-54-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; EISAI R & D MANAGEMENT CO., LTD.; REYNOLDS, Dominic; HAO, Ming-Hong; WANG, John; PRAJAPATI, Sundeep; SATOH, Takashi; SELVARAJ, Anand; (128 pag.)WO2016/164703; (2016); A1;,
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