These common heterocyclic compound, 53087-13-1, name is 1-(Benzyloxy)-3-bromobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 1-(Benzyloxy)-3-bromobenzene
Magnesium strip (1.29 g, 52.8 mmol) in anhydrous THF (50 mL)To the suspension was added iodine which was heated with magnesium.The mixture was refluxed and an approximately 5% solution of 3-bromobenzyl phenol(13.9 g, 52.8 mmol) was added.At the beginning of the reaction, the bromide solution is added dropwise and the mixture is then refluxed again1 hour. The mixture was cooled to about 5 C and a solution of cyclopentanone (4.44 g, 52.8 mmol) in THF (50 mL) was added dropwise. The mixture was stirred at rt for 72 h,The reaction was then quenched with a cooled saturated ammonium chloride solution and extracted with diethyl ether (x3). The organic phase was washed with brine, dried (Na2SO4), filtered and concentrated. The product was purified by silica gel chromatography (isohexane / EtOAc), which gave the title compound (8.5 g, 54%).
The synthetic route of 1-(Benzyloxy)-3-bromobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MEDIVIR AB; KALAYANOV, GENADIY; TORSSEL, STAFFAN; WAHLING, HORST; (130 pag.)TW2018/15396; (2018); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem