22483-09-6, name is 2,2-Dimethoxyethanamine, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 2,2-Dimethoxyethanamine
Dimethoxybenzaldehyde (12.20 g, 73.42 mmol) was dissolved in benzene (200 mL) and aminoacetaldehyde dimethyl acetal (12.0 mL, 11.7 g, 111 mmol) was added. The mixture was stirred at reflux for 4 h using a Dean-Stark trap. The reaction mixture was then concentrated and dissolved in CHCI3 (250 mL). The solution was washed with water (4 x 150 mL) and brine (150 mL), dried (Na2S04) and concentrated, and the last traces of solvent were removed under vacuum to provide the imine (18.41 g, 99.1%) as a light yellow solid: mp 50-52 C. 1H NMR (300 MHz, CDC13) delta 8.18 (s, 1 H), 7.42 (s, 1 H), 7.15 (d, / = 8.4 Hz, 1 H), 6.86 (d, / = 8.4 Hz, 1 H), 4.65 (t, / = 5.1 Hz, 1 H), 3.92 (s, 3 H), 3.90 (s, 3 H), 3.74 (d, / = 5.1 Hz, 2 H), 3.40 (s, 6 H).
The synthetic route of 22483-09-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PURDUE RESEARCH FOUNDATION; CUSHMAN, Mark, S.; SONG, Yunlong; WO2011/94416; (2011); A1;,
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