Electric Literature of 1758-46-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1758-46-9, name is 2-Phenoxyethylamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
0.137 g (1 mmol) of phenoxyethylamine, 1.0 mmol of triethylamine, Catalytic amount of 4-dimethylaminopyridine (DMAP), 20 mL of dichloromethane, 1.2 mmol of (R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenoxy]propanoyl chloride was added dropwise under ice bath The dichloromethane solution was dissolved in about 15 minutes and allowed to react at room temperature for 1 hour. After the reaction is completed, the organic layer is washed with water and washed with saturated brine. Dry, desolvent, The crude product was subjected to column chromatography [V petroleum ether: V ethyl acetate = 7:1 to 5:1] to afford white (R)-2-N-(2-phenoxyethyl)-2-[4-(6 -chloroquinoxaline-2-yloxy)phenoxy]propanamide, mp 150-153 C, yield 78.3%,
The synthetic route of 2-Phenoxyethylamine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Anhui Agricultural University; Tian Shengni; Yang Zihui; Ye Aihua; Huang Shixia; Li Junhong; Tian Qi; (8 pag.)CN108689921; (2018); A;,
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