In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 954235-83-7 as follows. HPLC of Formula: C7H4BrF3O
A mixture of l-bromo-2-(difluoromethoxy)-4-fluorobenzene (intermediate 176a, 150 mg), (4-(2- (4-(ethylsulfonyI)phenyl)acetamido)-2,6-difluorophenyl)boronic acid (intermediate 122a, 404 mg), tri-ierf-butylphosphine, tetrafluoroboric acid salt (217 mg), Pd2(dba)j (171 mg) and sodium carbonate solution (2 M, 1.245 mL) in 1,4-dioxane (4.5 mL) was sealed in a vessel and heated in the microwave at 100C for 45 mins. The reaction mixture was filtered through celite and silica gel. The filtrate was concentrated under reduced pressure and the residue was purified by MDAP to afford N-(2′- (difluoromethoxy) -2,4′,6-trifiuoro-[ 1 , 1 ‘-biphenyl] -4-yl) -2-(4-(ethylsulfonyl)phenyl) acetamide ( 133 mg) as a yellow solid. ?-NMR (400 MHz, DMSO-Patent; GLAXO GROUP LIMITED; WANG, Yonghui; CAI, Wei; LIU, Qian; MENG, Qinghua; CHENG, Yaobang; YANG, Ting; ZHANG, Guifeng; XIANG, Jianing; WU, Chengde; WO2013/29338; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem