Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1,4-Dibromo-2,5-dimethoxybenzene
The 1,4-dibromo-2,5-dimethoxybenzene (T-13) (25.0g, 84.47mmol, Tokyo Kasei Kogyo),4-methoxyphenyl boronic acid (T-14) (28.2g, 185.84mmol, Tokyo Kasei Kogyo),Bis (di – t-butyl (4-dimethylaminophenyl) phosphine) dichloropalladium (II)(0.30g, 0.42mmol),Trisodium phosphate dodecahydrate (96.33g, 253.42mmol),Tetrabutylammonium bromide (TBAB) (5.45g, 16.89mmol),Toluene (100ml), isopropanol (100ml)And water(100ml) were mixedIt was heated at reflux for 5 hours.The reaction mixture was allowed to cool to room temperature filtered,The filtrate was washed with water (200ml) and saturated brine (100ml) washedDried over anhydrous magnesium sulfate,Concentrated under reduced pressure.By column chromatography (the eluent:Toluene / ethyl acetate = 9/1 (volume ratio)) and the residue was purified,To obtain the compound (T-15) (27.9g, 84.47mmol, 94.3%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; JNC Co., Ltd.; JNC Petrochemical Co., Ltd.; Kobayashi, Masahide; Goto, Yasuyuki; Kobayashi, Takahiro; (94 pag.)CN105358523; (2016); A;,
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