Adding a certain compound to certain chemical reactions, such as: 19056-40-7, name is 4-Bromo-3-methoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19056-40-7, HPLC of Formula: C7H8BrNO
To a solution of 4-bromo-3-methoxyaniline (2.0 g, 9.9 mmol) in CH2Cl2 (25 mL) at 0 C. was added Et3N (4.1 mL, 29.7 mmol), followed by dropwise addition of Ac2O (1.4 mL, 14.9 mmol). The reaction mixture was stirred under argon at 0 C. for 0.5 hour and at room temperature overnight, diluted with CH2Cl2 (25 mL) and water (25 mL). The organic layer was further washed with 1 N acetic acid aqueous solution (25 mL), saturated NaHCO3 aqueous solution (25 mL), brine (25 mL), dried (MgSO4). Evaporation to dryness yielded the title product (2.2 g) as a tan solid. 1H NMR (300 MHz, DMSO-d6) delta 2.04 (s, 3H), 3.80 (s, 3H), 7.10 (dd, J=2.0 Hz and 8.6 Hz, 1H), 7.44 (m, 2H), 10.1 (s, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-methoxyaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Ruan, Fuqiang; (35 pag.)US2019/308963; (2019); A1;,
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