7252-83-7, name is 2-Bromo-1,1-dimethoxyethane, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 7252-83-7
To a solution of o-thiocresol (16. 89g, 136mmo1) in acetone (130ml) is added potassium carbonate (20. 5g, 148mmol) and a solution of bromoacetaldehyde dimethylacetal (19.93g, 123mmol) in acetone (20ml) and the reaction mixture is stirred at ambient temperature overnight. The solids are filtered and washed with diethyl ether. The filtrate is concentrated and dissolved into ethyl acetate, washed successively with water, 0.5 N NaOH, and 2N NaOH. The combined aqueous fractions are extracted with dichloromethane. The combined organic fractions are dried over anhydrous MgS04, filtered and concentrated to afford 1- [ (2, 2-dimethoxyethyl) thio] -2-methyl-benzene as a brown oil (23.4g, 90%) that is used without further purification.’H NMR (CDC13) : 8= 7.33 (1H, brd), 7.19-7. 08 (3H, m), 4.56 (1H, t), 3.38 (6H, s), 3.10 (2H, d), 2.42 (3H, s).
The synthetic route of 7252-83-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/92885; (2005); A1;,
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