In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6298-96-0 as follows. Safety of 1-(4-Methoxyphenyl)ethylamine
To 11.0 g (72.7 mmol) (S)-1-(4-methoxy-phenyl)-ethylamine is added carefully 30 mL HBr (30% in HOAc). The mixture is stirred at 100 C for 4 h. After cooling down to r.t., the solvent is removed in vacuo and the residue is dried in vacuo. The resultingproduct is used without further purification.C6H11NO*HBr (M= 218.1 g/mol)ESI-MS: 121 [M+H-NH3]+ Rt (HPLC): 0.50 min (method A)
According to the analysis of related databases, 6298-96-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; ROTH, Gerald Juergen; NOSSE, Bernd; HEINE, Niklas; WO2013/92616; (2013); A1;,
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