Electric Literature of 7252-83-7, A common heterocyclic compound, 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane, molecular formula is C4H9BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
DMF (1mL) imidazole-2-carboxaldehyde in (0.41 g, 4.27mmol) to a solution containing 1.1 equivalents of 2-bromo-1,1-dimethoxyethyl(0.79 g, 4.69 mmol) It was added potassium iodide potassiumcarbonate and a catalytic amount. The reaction was heated 18 hours at 110 C.,then to dryness and evaporated, and purified using Biotage SP4 in gradientmethod 5-50% in DCM, produces the desired compound (248 mg, 1. 35mmol, 32%yield).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MOLECULAR INSIGHT PHARMACEUTICALS INCORPORATED; BABICH, JOHN W; (133 pag.)JP5856247; (2016); B2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem