Electric Literature of 26583-60-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 26583-60-8 as follows.
EXAMPLE 12 2-{4-[2-Hydroxy-3-(2-(2-methyl-phenoxy)-ethylamino)-propoxy]-phenyl}-3-methyl-8-methoxy-3,4-dihydro-quinazolin-4-one This compound was prepared analogous to Example 2 from 2-[4-(1,2-epoxy-propoxy)-phenyl]-3-methyl-8-methoxy-3,4-dihydro-quinazolin-4-one and 2-(2-methyl-phenoxy)-ethylamine. M.p. of the hydrochloride: 120-125 C. Yield: 45% of theory. C28 H32 ClN3 O5 (526.04): Calc.: C-63.93%; H-6.13%; N-7.99%; Cl-6.73%. Found: C-63.81%; H-6.04%; N-8.03%; Cl-6.84%.
According to the analysis of related databases, 26583-60-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Dr. Karl Thomae Gesellschaft mit beschrankter Haftung; US4379788; (1983); A;,
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