Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, A new synthetic method of this compound is introduced below., Product Details of 2674-34-2
A flame dried RBF was charged with l,4-dibromo-2,5-dimethoxybenzene (1) (10.3 g, 39.6 mmol, 1.0 equiv.), phenylboronic acid (9.92 g, 81.4 mmol, 2.05 equiv.), potassium carbonate (19.2 g, 139 mmol, 3.5 equiv.), toluene (80 mL), deionized water (40 mL), and a stir bar. Pd(PPh3)4 (457 mg, 0.395 mmol, 1 mol%) was added last to the flask before the reaction mixture was lowered into a bath that was preheated to 90 C and stirred for l2h with a condenser. Upon completion, the reaction was diluted with water, extracted 3 times with DCM, dried on MgS04, and concentrated via rotary evaporation. The solid was then recrystallized in EtOH to provide 9.01 g (31.1 mmol, 78% yield) of white needles. NMR (500 MHz, CDCb): d 7.61-7.59 (m, 4H), 7.46-7.43 (m, 4H), 7.38-7.34 (m, 2H), 6.99 (s, 2H), 3.80 (s, 6H). 13C NMR (125 MHz, CDCb): d 150.6, 138.3, 130.4, 129.4, 128.1, 127.1, 114.8, 56.4. HRMS (TOF-EI, m/z) calcd. for C20H18O2 [M]+: 290.1307; found: 290.1300.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; LEHIGH UNIVERSITY; CHEN, Mark; WEHRMANN, Caleb; CHARLTON, Ryan; (58 pag.)WO2019/226678; (2019); A2;,
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