Adding a certain compound to certain chemical reactions, such as: 4179-19-5, name is 3,5-Dimethoxytoluene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4179-19-5, Safety of 3,5-Dimethoxytoluene
Step 1: Put 1,3-dimethoxy-5-methylbenzene (30g, 0.20mol)And dichloromethane (900 mL) were added to a dry round bottom flask (1 L), and the above solution was added dropwise with dichlorosulfone (52.5 g, 0.40 mol) under ice-cooling,After the addition was complete, the mixture was stirred at room temperature overnight.After completion of the reaction, aqueous NaHCO3 solution was added dropwise to adjust the pH = 8, and dichloromethane was extracted.Wash with dilute hydrochloric acid and distilled water,Dry and concentrate under reduced pressure to obtain compound 2,4-dichloro-1,5-dimethoxy-3-methylbenzene(31g, white solid),Used directly in the next step.
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Reference:
Patent; Rudong Lingda Bio-pharmaceutical Technology Co., Ltd.; Wan Huixin; Pan Jianfeng; Ma Jingui; (63 pag.)CN110857300; (2020); A;,
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