Electric Literature of 946-80-5,Some common heterocyclic compound, 946-80-5, name is Benzyl Phenyl Ether, molecular formula is C13H12O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a 10 mL sealed tubewas added anisole (108 mg, 1.0 mmol), aceticanhydride (204 mg, 2.0 mmol) and catalyst (2.5 mol%). Then the mixture wasstirred at room temperature until complete consumption of starting material asmonitored by TLC or GC-MS analysis. Then the reaction mixture was evaporated invacuum, and CH2Cl2 (3¡Á10 ml) was added to the reactionmixture. The catalyst was then filtered out for the next cycle of reaction. Thecombined CH2Cl2 solution was removed by evaporation invacuum and was then subject to silica gel column chromatograph.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Benzyl Phenyl Ether, its application will become more common.
Reference:
Article; Zhang, Xiaohong; Xu, Xinhua; Li, Ningbo; Liang, Zhiwu; Tang, Zilong; Tetrahedron; vol. 74; 15; (2018); p. 1926 – 1932;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem