Extracurricular laboratory: Synthetic route of 41789-95-1

According to the analysis of related databases, 41789-95-1, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41789-95-1, name is 1-(3-Methoxyphenyl)-N-methylmethanamine, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C9H13NO

A solution of (3-methoxy-benzyl)-methyl-amine (0.590 g, 3.93 mmol) and TEA (1.1 ml_) in DCM (5 mL) was treated with 2-bromo-1-thiophen-3-yl-ethanone (1.11 g, 5.11 mmol). After 16 h at 23 0C, the mixture was poured onto water and extracted with DCM. The organic layer was collected, dried (Na2SO4), and concentrated to give the desired product (1.149 g, >100% crude). 1H NMR (CDCI3): 8.24 (ddLambda J = 2.9,’ 1.2, 1 H), 7.57 (dd, J = 5.1 , 1.2, 1 H), 7.28 (dd, J = 5.1 , 2.9, 1 H), 7.26-7.21 (m, 1 H), 6.94-6.90 (m, 2H), 6.83-6.79 (m, 1 H), 3.79 (s, 3H), 3.65 (s, 2H), 3.64 (s, 2H), 2.37 (s, 3H).

According to the analysis of related databases, 41789-95-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2006/66197; (2006); A1;,
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