Electric Literature of 36865-41-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 36865-41-5 as follows.
Step 1: Into a 500-mL 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed 1-bromo-3-methoxypropane (60 g, 393.0 mmol), triphenylphosphine (102.8 g, 393.1 mmol) and toluene (300 mL). The resulting solution was stirred for 16 h at 150 C. in an oil bath. The solids were collected by filtration. This resulted in (3-methoxypropyl)triphenylphosphonium bromide (120 g, 91% yield) as a white solid.
According to the analysis of related databases, 36865-41-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Enanta Pharmaceuticals, Inc.; Panarese, Joseph; Bartlett, Samuel; Chong, Katherine; Or, Yat Sun; (120 pag.)US2019/224188; (2019); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem