Related Products of 123652-95-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 123652-95-9, name is (3-Fluoro-4-methoxyphenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
[00326] To a solution of compound 15 (2.3 g, 13.5 mmol) in SOd2 ( 20 mL) was refluxed for 4h, The mixture was concentrated and then re-dissolved in DCM (5 mL) and transfeffed to a solution of the amine 2 ( 2.7 g 17.6 mmol) and TEA (4.0 g, 40.5 mmol). The mixture was stirred at rt for 3 h. The resulting mixture was purified by FCC (PE/EA=3:1) to afford the product 16 (3.lg, 75.3%). ?H NMR (400 MHz, CDC13): 8.19 (d, J =4.8 Hz, 1H), 7.11-7.06 (m, 3H), 6.92(t, J = 8.8 Hz, 1H), 6.32-6.28 (m, 1H), 4.55 (d, J = 6.0 Hz, 2H), 3.87 (s, 3H), 2.34 (s, 3H); mlz (ESI+) (M+H)+ = 309.00.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (3-Fluoro-4-methoxyphenyl)methanamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; YANG, Wenjin; CHEN, Che-Hong; MOCHLY-ROSEN, Daria; WO2014/160185; (2014); A2;,
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