Application of 1978-39-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1978-39-8 as follows.
Example 1 (3) obtained in 2 – [[5-phenyl-4-(lH-pyrrol-1-yl)-4H-1,2,4-triazol-3-yl] thio] acetic acid (90 mg, 0.3mmol),1-hydroxybenzotriazole (40mg, 0.3mmol),1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (60 mg, 0.3 mmol)Of N, N-dimethylformamide (2 ml)Was added triethylamine (0.09ml, 0.6mmol)When the 5-fluoro-2-methoxy aniline (0.04ml, 0.36mmol)Was stirred for 16 hours at room temperature added.The reaction solution was extracted by adding aqueous sodium bicarbonate solution and ethyl acetate, and extracted twice further the aqueous layer with ethyl acetate. After acidification with 1N hydrochloric acid was added to the organic layer, extracted, extracted twice further the aqueous layer with ethyl acetate. The organic layer was washed with saturated brine, and dried with anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, the residue was purified by column (hexane: ethyl acetate = 1: 3-1: 5) to give to N-(5-fluoro-2-methoxyphenyl) -2 – [[5-phenyl to give-4- (lH-pyrrol-1-yl) -4H-1,2,4- triazol-3-yl] thio] acetamide (20mg, 16%) as a pale brown solid.
According to the analysis of related databases, 1978-39-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chiba Prefecture; Nakagawara, Akira; Hoshino, Tadatsugu; Nakamura, Yoko; (15 pag.)JP2015/117182; (2015); A;,
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