Electric Literature of 31576-51-9, These common heterocyclic compound, 31576-51-9, name is 2-(2-Methoxyethoxy)ethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 4-mercapto-4-nnethylpentanoic acid (226 pl_, 251 mg, 1 .69 mmol) in CHC were added 2-(2-methoxyethoxy)ethanamine (249 mI_, 242 mg, 2.03 mmol) and N-ethyl-N’-(3- dimethylaminopropyl)carbodiimide hydrochloride (0.35 g, 1 .82 mmol). The mixture was stirred for 1.5h, heated to 60 C for 2h and subsequently stirred at rt for 3d. The reaction mixture was then purified by silica chromatography (50% EtOAc in heptane EtOAc). The desired product was obtained as a colorless oil (0.23 g, 0.29 mmol, 54%). 1 H NMR (400 MHz, CDCI3) d (ppm) 6.20- 6.00 (bs, 1 H), 3.65-3.60 (m, 2H), 3.59-3.53 (m, 4fH), 3.49-3.44 (m, 2H), 3.40 (s, 3H), 2.40-2.33 (m, 2H), 1.96-1.88 (m, 2H), 1.63 (bs, 1 H), 1 .38 (d, J = 0.5 Hz, 6H).
Statistics shows that 2-(2-Methoxyethoxy)ethanamine is playing an increasingly important role. we look forward to future research findings about 31576-51-9.
Reference:
Patent; SYNAFFIX B.V.; VERKADE, Jorge Merijn Mathieu; HOOGENBOOM, Jorin; VAN BERKEL, Maria Antonia; VAN DELFT, Floris Louis; (95 pag.)WO2019/110725; (2019); A1;,
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