Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22236-10-8, name is 4-(Difluoromethoxy)aniline, This compound has unique chemical properties. The synthetic route is as follows., name: 4-(Difluoromethoxy)aniline
Preparation 110; 2, 6-dichloro-4- (difluoromethoxy) phenylamine; To a solution of 4-[(difluoromethoxy) methyl] aniline (15.0 g, 94.3 mmol) in acetonitrile (150 ml) was added N-chlorosuccinimide (25.2 g, 18.9 mmol) and the reaction mixture was stirred under nitrogen for 2 h. The reaction mixture was concentrated in vacuo and the residue was partitioned between diethyl ether (500 ml) and water (125 ml). The organic layer was separated, washed with aqueous sodium thiosulphate solution, water and brine, dried (MgS04) and treated with charcoal. The solution was then filtered and concentrated in vacuo. The residue was extracted with hexane (2 x 300 mi) and the combined extracts were concentrated in vacuo to give the titled compound (13.8 g). Experimental MH+ 228. 0; expected 228.0
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 22236-10-8.
Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/90313; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem