Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1663-61-2, name is (Triethoxymethyl)benzene, A new synthetic method of this compound is introduced below., name: (Triethoxymethyl)benzene
General procedure: The starting hydrazide 5a,b (10.0 mmol) was added to a mixture of the triethyl orthoester (15.0 mmol) and glacial AcOH (10 mL). The mixture was kept under reflux until the starting hydrazide was fully consumed (monitored by TLC, 1?4 h). After cooling, the excess orthoester and AcOH were evaporated under reduced pressure. The crude product 7a?f was subjected to silica gel column chromatography (benzene?EtOAc, 1:3) or was crystallised (benzene?hexanemixtures).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Kudelko, Agnieszka; Jasiak, Karolina; Synthesis; vol. 45; 14; (2013); p. 1950 – 1954;,
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