In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 136468-19-4, name is 5-Methoxy-6-methyl-2,3-dihydro-1H-inden-2-amine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 5-Methoxy-6-methyl-2,3-dihydro-1H-inden-2-amine
102.63 g of intermediate 34 (0.5 mol) and 56.11 g of potassium hydroxide (1 mol) were added to 1100 ml of xylene at room temperature and heated to 120 C under stirring for 0.5 hour. The reaction was monitored by TLC until the reaction solution Drop to room temperature, add water 1100ml, extracted with methylene chloride 500ml * 3 times, combined organic phase, washed 500ml * 3 times, saturated salt water 500ml * 1 times, anhydrous sodium sulfate after drying, the yellow oily liquid 80g; After the addition of 400ml ethyl acetate dissolved, the hydrogen chloride gas to pH = 1 ~ 2, precipitated a large amount of white solid, filter, with a small amount of ethyl acetate leaching filter cake, dried white solid 91.89g (yield 86% ) To give compound 3:
The synthetic route of 136468-19-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Longxining (Shanghai) Pharmaceutical Technology Co., Ltd; ZHU, NING; LI, CHUN CHENG; ZHU, XIAN MING; (13 pag.)CN105884626; (2016); A;,
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