Reference of 112970-44-2,Some common heterocyclic compound, 112970-44-2, name is 2-Bromo-3-methoxyaniline, molecular formula is C7H8BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To 2-bromo-3-aminoanisole 2b4 (750mg, 3.7mmol, 1eq) was added imidate2g2 (0.73g, 3.7mmol, 1eq) in ethanol (7 ml) under a N2 atmosphere. The mixture wasstirred at R.T. for 24 hrs at which point the reaction was concentrated and purifieddirectly on a silica gel column (eluent: EtOAc/Hexanes (1:9)) to afford adduct 2o1(1.12g, 88%) as a pale yellow oil. MS: 344 (M + H)+ and 346 (MH + 2)+.
The synthetic route of 112970-44-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GmbH & CO KG; WO2006/85; (2006); A1;,
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