Synthetic Route of 109-85-3, The chemical industry reduces the impact on the environment during synthesis 109-85-3, name is 2-Methoxyethylamine, I believe this compound will play a more active role in future production and life.
To a colorless solution of methyl 3-fluoro-4-nitrobenzoate (50 g, 250 mmol) in THF (400 ml_) was added triethylamine (40.7 g, 402 mmol, 55.8 ml_) followed by addition of 2- methoxyethanamine (30.2 g, 402 mmol) in THF (100 ml_), drop-wise, at room temperature. The resultant yellow solution was stirred at 55 C for 18 hours. The solution was cooled to room temperature and concentrated under reduced pressure to remove THF. The resultant yellow solid was dissolved in EtOAc (800 ml_) and washed with saturated aqueous ammonium chloride solution (250 ml_). The aqueous phase was separated and extracted with EtOAc (200 ml_). The combined organic layers were washed with saturated aqueous sodium chloride solution (3 x 250 ml_), dried over sodium sulfate, filtered, and concentrated under reduced pressure to yield C49 (60.2 g, 94%) as a yellow solid. 1H NMR (CDCb) d 8.23 (d, 1 H), 8.17 (br s, 1 H), 7.58 (d, 1 H), 7.25 (dd, 1 H), 3.95 (s, 3H), 3.69 – 3.73 (m, 2H), 3.56 (m, 2H), 3.45 (s, 3H); LCMS m/z 255.4 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxyethylamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PFIZER INC.; ASPNES, Gary Erik; BAGLEY, Scott W.; CONN, Edward L.; CURTO, John M.; EDMONDS, David James; FLANAGAN, Mark E.; FUTATSUGI, Kentaro; GRIFFITH, David A.; HUARD, Kim; LIMBERAKIS, Chris; MATHIOWETZ, Alan M.; PIOTROWSKI, David W.; RUGGERI, Roger B.; (149 pag.)WO2019/239371; (2019); A1;,
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