In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24988-36-1, name is 1,5-Dibromo-2,4-dimethoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 24988-36-1
Add to the dry three-necked flask with a magnetic rotor 1,3-dibromo-4,6-dimethoxybenzene (1.8644 g, 6.1 mmol, 97%, 1.0 eq.), 3-biphenylboronic acid (2.7157 g, 13.4 mmol, 98%, 2.2 eq.).palladium acetate (0.0411 g, 0.18 mmol, 0.03 equivalents)And the ligand S-Phos (0.1536 g, 0.37 mmol, 98%, 0.06 equivalents).Nitrogen gas was distilled off three times, and then an aqueous solution (12 mL) of 1,4-dioxane (36 mL) and potassium carbonate (4.2218 g, 30.5 mmol, 5.0 eq.The three vials were then placed in a 100 C oil bath.After stirring for 24 hours, the reaction was monitored by thin layer chromatography. After cooling to room temperature, the organic phase was separated and aqueous was extracted with ethyl acetate (30mL¡Á2).All organics were combined, dried over anhydrous sodium sulfate, filtered, concentrated and the crude product Purification by flash column chromatography on silica gel (eluent: petroleum ether / ethyl acetate = 50/1) to give A4, white solid 4.0225 g, yield 90%.
The synthetic route of 24988-36-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang University of Technology; Li Guijie; Dai Jianxin; Chen Shaohai; Feng Qi; (28 pag.)CN110183476; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem