Synthetic Route of 2734-70-5, These common heterocyclic compound, 2734-70-5, name is 2,6-Dimethoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a 0.5 M solution of the acid 9/10 in dichloromethane under nitrogen atmosphere, was added oxalyl chloride (2 eq.) and a few drops of DMF at room temperature. After effervescence subsided, the mixture was heated to reflux at 45 ¡ãC for 2 h. It was then cooled to room temperature, concentrated in vacuo, co-evaporated three times with toluene and then re-dissolved in dichloromethane. The aniline (2 eq.) was then added at 0 ¡ãC, followed by DIPEA (3 eq.) and the mixture stirred overnight at room temperature. The reaction was quenched by addition of NaHCO3 and the aqueous layer was extracted three times with dichloromethane. The combined organic layer was washed once with brine, dried over Na2SO4 and concentrated in vacuo. Purification by silica gel chromatography using a toluene/acetone or dichloromethane/methanol solvent system gave access to the pure protected amides (30percent?75percent yields).
The synthetic route of 2734-70-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chofor, Rene; Risseeuw, Martijn D.P.; Pouyez, Jenny; Johny, Chinchu; Wouters, Johan; Dowd, Cynthia S.; Couch, Robin D.; Van Calenbergh, Serge; Molecules; vol. 19; 2; (2014); p. 2571 – 2587;,
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