Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 366-99-4, name is 3-Fluoro-4-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 3-Fluoro-4-methoxyaniline
Step 2. To a solution of l-(6-chloropyrazin-2-yl)-2-methyl-lH-benzo[d]imidazole (96 mg, 0.36 mmol) and 3-fluoro-4-methoxyaniline (71 mg, 0.5 mmol) in THF (1 mL) at room temperature was added KOt-Bu (1M in THF, 1 mL, 1 mmol). The mixture was reacted for 5 minutes, then the reaction was quenched with AcOH and the product partitioned between ethyl acetate and aqueous ammonium chloride. The organic layer was dried, concentrated and purified by chromatography on silica gel (gradient from ethyl acetate:hexane 1:2 to ethyl acetate: methanol 5: 1). The fractions were concentrated and the residue was washed with an ethyl acetate: ether mixture, then filtered and dried to provide the title compound as a yellow/brown solid (39 mg, 25 percent). ]H NMR (DMSO-i delta 9.93 (s, 1H), 8.31 (s, 1H), 8.25 (s, 1H), 7.61 – 7.68 (m, 2H), 7.51 – 7.55 (m, 1H), 7.32 – 7.36 (m, 1H), 7.26 – 7.26 (m, 1H), 7.23 – 7.30 (m, 2H), 7.14 (t, J = 9.1 Hz, 1H), 3.79 (s, 3H), 2.63 (s, 3H); MS m/z 350 (ESI) [M+H]+.
According to the analysis of related databases, 366-99-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PTC THERAPEUTICS, INC.; BAIAZITOV, Ramil; CHOI, Soongyu; DU, Wu; HWANG, Seongwoo; LEE, Chang-Sun; LIU, Ronggang; MOON, Young-Choon; PAGET, Steven, D.; REN, Hongyu; SYDORENKO, Nadiya; WILDE, Richard, Gerald; WO2015/76800; (2015); A1;,
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