Reference of 1535-73-5, A common heterocyclic compound, 1535-73-5, name is 3-Trifluoromethoxyaniline, molecular formula is C7H6F3NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of compound 3B-1 (2.00 g, 8.98 mmol, 1.0 eq) and compound 3D-1 (1.91 g, 10.8 mmol, 1.2 eq) in isopropanol (20 mL) was added TFA (1.02 g, 8.98 mmol, 1.0 eq) in one portion at 20 ¡ãC under nitrogen. The mixture was stirred at 90 ¡ãC for 18 hours. LC-MS (ET15060-21-P1A1) showed the reaction was completed. The resulting suspension was cooled, and the product was filtered off, washing with a small volume of dichloromethane (10 mL) to give compound 3D-2 (3.00 g, 8.26 mmol, 91.9 percent yield) as yellow solid which was used for next step directly. ln NMR: ET15060-21-P1A1 400 MHz DMSO-d6 9.68 (s, 1H), 8.71 (d, J = 8.8 Hz, 1H), 8.15 (d, J = 6.0 Hz, 1H), 8.03 (s, 1H), 7.91 (dd, J = 8.4, 1.2 Hz, 1H), 7.71 (d, J = 8.4, Hz, 1H), 7.45 (t, J = 8.4 Hz, 1H), 6.98 (d, J = 8.0 Hz, 1H), 6.90 (d, J = 6.0 Hz, 1H), 2.48 (s, 3H).
The synthetic route of 1535-73-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LUTRIS PHARMA LTD.; SHELACH, Noa; (76 pag.)WO2019/26065; (2019); A2;,
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