Application of 645-36-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 645-36-3 as follows.
In a 100 mL flask, 3-fluoro-4-((phenoxycarbonyl)amino)benzoic acid methyl ester was added(3. 3 g, 11. 4 mmol, 1 Oeq.),2, 2-diethoxyethanamine (1.28 g, 13. 68 mmol, 1.2 eq.),piperidine (1.4 ml, 17.1 mmol, 1.5 eq.)And 6 mL of N, N-dimethylformamide,95 degrees Celsius heating and stirring 15h.To the reaction solution was added lmL concentrated hydrochloric acid for quenching,Then 40 mL of water was added to extract with ethyl acetate (40 X 3)The organic phases were combined,The organic phase was washed with saturated brine (40 mL)Dried over anhydrous Na2S04, filtered, and the organic solvent was distilled off under reduced pressure to give a brown liquid (3.3 g, Y = 89%)
According to the analysis of related databases, 645-36-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Hubei Xinxiwang Bio-technology Co.,Ltd; xiao, hong; (19 pag.)CN105294567; (2016); A;,
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