Adding a certain compound to certain chemical reactions, such as: 5961-59-1, name is 4-Methoxy-N-methylaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5961-59-1, Recommanded Product: 5961-59-1
[[00146]] To a mixture of N-methyl-p-anisidine (2.8 g, 20 mmol) and malonic acid (4.3 g, 40 mmol) was added POC13 (17 mL). After heating at [90¡ã] C for 1.5 hr, the reaction mixture was poured over ice and basified with 6N [NAOH] to a pH of 14. The solution was then filtered and the filtrate was acidified with, 6N HC1 to pH 3. The precipitate was filtered and dried to afford a brown solid (1.8 g, [50percent). H] NMR (300 MHz, [MEOD-] d4) [8] 3.65 (3H, s), 3.86 (3H, s), 5.97 [(1H,] s), 7.28 [(1H,] dd, J [=] 2.8, 9.3 Hz), 7.49 (2H, d, J = 9.3 Hz).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Methoxy-N-methylaniline, and friends who are interested can also refer to it.
Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; WO2003/106452; (2003); A2;,
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