Adding a certain compound to certain chemical reactions, such as: 67191-35-9, name is 1-Isopropoxy-2-vinylbenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 67191-35-9, Recommanded Product: 1-Isopropoxy-2-vinylbenzene
Under anhydrous and anaerobic conditions,Grubbs first generation catalyst 1a (1.22mmol)Add to a 100mL Schlenk bottle,Compound IIIaa (2858 mg, 2.43 mmol) andPotassium tert-butoxide (286 mg, 2.55 mmol)Add to the reaction bottle,Add 50 mL of n-hexane.After reacting at 60 C for 5 hours with stirring,TLC monitored the reaction completely.After the reaction was completed, n-hexane was removed under reduced pressure.The intermediate obtained in the previous step was dissolved in 40 mL of dichloromethane.Add cuprous chloride (300 mg, 1.42 mmol) and stir for 5 min.Compound 2a1 (296 mg, 1.82 mmol) was added to the reaction flask and the temperature was raised to 40 C.TLC monitored the reaction completely.After completion of the reaction, column chromatography gave 574 mg of light green solid powder IIaa1, yield: 32.3%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Isopropoxy-2-vinylbenzene, and friends who are interested can also refer to it.
Reference:
Patent; Chengdu Kaimeisi Business Wu Information Advisory Center (Limited Partner); Chen Jianxin; (28 pag.)CN110041262; (2019); A;,
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