Synthetic Route of 123652-95-9, The chemical industry reduces the impact on the environment during synthesis 123652-95-9, name is (3-Fluoro-4-methoxyphenyl)methanamine, I believe this compound will play a more active role in future production and life.
To a screw-capped vial equipped with a magnetic stir bar were added 3,4- dimethylthieno[2,3-c]pyridazine-6-carboxylic acid (Intermediate 2) (35 mg, 0.17 mmol), DMF (1 mL), DIEA (90 tL, 0.48 mmol), and HATU (77 mg, 0.20 mmol). This mixture was allowed to stir at ambient temperature for 30 minutes, and then excess (3-fluoro-4- methoxyphenyl)methanamine (2.1) was added. After stirring at room temperature for 30 minutes, purification by reversed-phase HPLC (eluting with water/0. 1% trifluoroacetic acid and acetonitrile) afforded the title compound. LCMS: RT = 0.81 mm, >99% 254 nm,>99% 215 nm; mlz (M + 1)= 346. ?H NMR (400 MHz, d6-DMSO) oe 9.5 (t, J= 5.8 Hz, 1H), 8.3 (s, 1H), 7.1-7.3 (m, 3H), 4.5 (d, J= 5.8 Hz, 2H), 3.8 (s, 3H), 2.7 (s, 3H), 2.6 (s, 3H); HRMS calculated for C,7H,6FN302S (M+H) mlz: 346.1026, measured: 346.1023.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (3-Fluoro-4-methoxyphenyl)methanamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; VANDERBILT UNIVERSITY; LINDSLEY, Craig, W.; CONN, P., Jeffrey; WOOD, Michael, R.; POSLUSNEY, Michael, S.; TARR, James, C.; MELANCON, Bruce, J.; WO2015/27214; (2015); A1;,
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