Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1484-26-0, name is 3-Benzyloxyaniline, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Benzyloxyaniline
Anhydrous potassium carbonate (74 g, 0.535 mol) was sequentially added to benzyl alcohol (200 g, 1.86 mol, 192 ml).m-Dinitrobenzene (30g, 0.178mol),Stirring, reacting at 110 C for 24 h, cooling in an ice water bath, and filtering off inorganic salts by suction;Add Raney nickel (10g) to the filtrate.Passing hydrogen gas, pressure 2.5~3MPa, internal temperature 80C, reaction for 15h, and recovering nickel by filtration;The filtrate was distilled under reduced pressure, and after removing benzyl alcohol, 50 mL of ethanol was added to the residue, and the mixture was stirred for 2 hours in an ice water bath to precipitate a solid.Drying gives 9.3 g of aminophenol in an off-white solid.The yield was 48%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shanghai University of Engineering Science; Xu Jingli; Shen Yongjia; Mao Yongjun; Wang Han; (7 pag.)CN109942441; (2019); A;,
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