In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1515-95-3 as follows. HPLC of Formula: C9H12O
General procedure: In a 25 ml dry round-bottom flask was suspended polymeric PhIO (0.25 equivalent) indry acetonitrile at 23C. Then, Al(NO 3 ) 3 (0.35 equivalent) was added and stirred for10 min, afterward, it was cooled to 0C. The benzylic aryl derivative (1 equivalent) wasincorporated in one portion. The reaction was warmed to 23C for a period of 2-4 huntil the starting material was fully consumed judging its advance by TLC. The reactionmixture was quenched by the addition of NH 4 Cl saturated solution (25 mL) and thenextracted with EtOAc (3 10 mL). The organic extracts were collected, dried overanhydrous sodium sulfate, filtered, and concentrated in vacuo to remove the solventand yield the crude of the reaction. The product was purified by flash column chroma-tography on silica gel (100-200 mesh) with EtOAc/hexane system.
According to the analysis of related databases, 1515-95-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Yahuaca-Juarez, Berencie; Gonzalez, Gerardo; Ramirez-Morales, Marco A.; Alba-Betancourt, Calara; Deveze-Alvarez, Martha A.; Mendoza-Macias, Claudia L.; Ortiz-Alvarado, Rafael; Juarez-Ornelas, Kevin A.; Solorio-Alvarado, Cesar R.; Maruoka, Keiji; Synthetic Communications; vol. 50; 4; (2020); p. 539 – 548;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem