Synthetic Route of 126-38-5,Some common heterocyclic compound, 126-38-5, name is 1-Bromo-2,2-dimethoxypropane, molecular formula is C5H11BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To 4-bromopyridin-2-amine (1.08 g, 6.24 mmol)Add in H2O (20mL) solution1-bromo-2,2-dimethoxypropane (5.59 g, 30.5 mmol)And 4-methylbenzenesulfonic acid (209.4 mg, 1.216 mmol).The reaction mixture was heated to reflux and stirred for 12 hours.After the reaction,Adjust to pH=10 with a saturated aqueous solution of Na2CO3.The resulting mixture was extracted with EtOAc (100 mL¡Á3).The combined organic phases were dried over anhydrous sodium sulfate.Filter and concentrate under reduced pressure.The residue was purified by silica gel column chromatography (EtOAc /EtOAcThe title compound was obtained as a yellow solid (750 mg, yield 57%).
The synthetic route of 126-38-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Peng Ju; Li Xiaobo; Zhang Tao; Hu Haiyang; Chen Wuhong; Bai Changlin; Ke Donghua; Chen Peng; (217 pag.)CN109776522; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem