Adding a certain compound to certain chemical reactions, such as: 22236-10-8, name is 4-(Difluoromethoxy)aniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 22236-10-8, category: ethers-buliding-blocks
General procedure: To a solution of ethyl 4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzoate (7) (1 mmol) in ethanol, aryl amines 8 (1 mmol) were added and the resulting mixture was refluxed for 5 – 6 h. The reaction was monitored by TLC. After the completion of the reaction, ethanol was distilled under reduced pressure, and the residue was treated with 10% NaHCO3 solution (20 mL). The aqueous phase was extracted with ethyl acetate (2 x 20 mL) and dried over anhydrous sodium sulphate, which was concentrated to give crude products which were purified by column chromatography over silica gel using chloroform-ethyl acetate (9:1; v:v) as eluent to give pure ethyl 4-(4-(arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzoate 9.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Difluoromethoxy)aniline, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Roopashree, Rangaswamy; Swaroop, Toreshettahally Ramesh; Jagadish, Swamy; Mohan, Chakrabhavi Dhananjaya; Rangappa, Kanchugarakoppal Subbegowda; Letters in drug design and discovery; vol. 11; 10; (2014); p. 1143 – 1148;,
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