In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 54149-17-6 as follows. Application In Synthesis of 1-Bromo-2-(2-methoxyethoxy)ethane
Syntheses of Monofunctional Azides:1-Azido-2-(2-methoxyethoxy)ethane, 19. A solution of 1-bromo-2-(2-methoxyethoxy) ethane (12.4 g, 67.8 mmol) and sodium azide (13.2 g, 203 mmol) in water (150 ml) was stirred under reflux for 16 hours. The aqueous phase was extracted with dichloromethane (2¡Á200 ml), dried with MgSO4 and evaporated to dryness, to give 19 as a colorless oil in 87.3% yield. 1H NMR (500 MHz, CDCl3): delta=3.29 (s, CH3O, 3H), 3.30 (t, J=5.2 Hz, CH2N3, 2H), 3.44-3.48 (m, CH3OCH2, 2H), 3.53-3.60 (m, CH2OCH2, 4H). 13C NMR (125 MHz, CDCl3): delta=50.89 (s, CH2N3, 1C), 59.27 (s, CH3O, 1C), 70.29 (s, CH3OCH2CH2, 1C), 70.84 (s, CH3OCH2CH2, 1C), 72.21 (s, CH2CH2N3, 1C).
According to the analysis of related databases, 54149-17-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; The Scripps Research Institute; US2009/69561; (2009); A1;,
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