Reference of 701-56-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 701-56-4, name is 4-Methoxy-N,N-dimethylaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
4-(N,N-dimethylamino)-3-nitrosoanisole (123). To a stirred solution of N,N-dimethylanisidine 122 (3.09 g, 20.4 mmol) in 5% HCI (30 ml. ), NaNO2 (1.94 g, 28.2 mmol) in 10 mL water was added dropwise upon ice/water bath cooling, and reaction was stirred for 15 min. The mixture was poured in 200 mL of 3N NaOAc (200 mL) and extracted with EtOAc (3 x 150 mL). The combined extract was washed with sat. NaHCO3 (200 mL), brine (200 mL), dried over Na2SO4 and evaporated to give nitroso derivative 123 (3.68 g, 100%) as brown solid.
The synthetic route of 4-Methoxy-N,N-dimethylaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; INVITROGEN CORPORATION; WO2008/76524; (2008); A2;,
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