Application of 171290-52-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 171290-52-1 as follows.
To a mixture of compound 97 (6.78 g), compound 98 (10.0 g), cuprous iodide (340 mg), bistriphenylphosphine palladium dichloride (1.25 g) and triethylamine (14.7 mL) at room temperature DMF, nitrogen replacement three times, rise to 80 and stir overnight, add water, extract with ethyl acetate, the extract was washed with saturated sodium chloride aqueous solution, dried over anhydrous sodium sulfate, the solvent was removed, the residue was separated by column chromatography, Target product (10.5g).
According to the analysis of related databases, 171290-52-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shou Yao Konggu (Beijing) Co., Ltd.; Wang Jinghan; Yao Jinsuo; Duan Xiaowei; Yuan Baokun; Sun Ying; Lu Chang; (42 pag.)CN110950867; (2020); A;,
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