Electric Literature of 1484-26-0, A common heterocyclic compound, 1484-26-0, name is 3-Benzyloxyaniline, molecular formula is C13H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Synthesis of Compound 113To a stirred solution of compound 1703 (200 mg, 1.26 mmol) in DCM (10 rnL) was added N-methylmorpholine (0.41 rnL, 3.79 mmol) and 3-benzyloxy-phenylamine (251 mg, 1.26 mmol) at 00C. The reaction mixture was stirred at room temperature overnight. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was concentrated under vacuum to remove DCM. The residue was dissolved in water and extracted with ethyl acetate (2 x 50 mL), and the organic layer was washed with brine and dried over anhydrous sodium sulfate to afford coupled product 113 (120 mg, 28percent) with HPLC purity of 91.4percent. Mass: 340 [M+H]; 1H NMR (500 MHz, CDCl3): delta 1.35 (m, 5H), 1.6-1.85 (m, 6H), 4.1 (d, IH), 5.1 (s, 2H), 6.78 (m, IH), 7.08 (m, IH), 7.2-7.6 (m, 7H), 8.38 (s, IH).
The synthetic route of 1484-26-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARETE THERAPEUTICS, INC.; WO2008/73623; (2008); A2;,
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