Electric Literature of 645-36-3,Some common heterocyclic compound, 645-36-3, name is 2,2-Diethoxyethanamine, molecular formula is C6H15NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Benzaldehyde (1.58 mL, 15.72 mmol) and 2,2-diethoxyethanamine (3.15 g, 23.58 mmol, 1.5 equiv) were stirred at room temperature for 30 minutes. Triacetoxyborohydride (10 g, 47.18 mmol, 3.0 equiv) was diluted slowly in tetrahydrofuran (150 mL, 10 vol) and slowly added dropwise. The reaction mixture was stirred at room temperature for 12 hours. After the reaction was completed, the mixture was diluted with ethyl acetate (200 mL, 15 vol) and washed once with saturated sodium bicarbonate (200 mL, 15 vol) and water (200 mL, 15 vol). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (n-hexane: ethyl acetate)=1:1 (v/v) to obtain the target compound (3 g, 87%).
The synthetic route of 645-36-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hanmi Pharm Co., Ltd.; Bae In-hwan; Park Chang-hui; Ahn Yeong-gil; (28 pag.)KR2019/40763; (2019); A;,
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