Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 54314-84-0, name is ((3-Bromopropoxy)methyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., name: ((3-Bromopropoxy)methyl)benzene
To a solution of methyl [2- (4-HYDROXYPHENOXY)-2-METHYLBUTANOATE] (5g, 22. [32MMOL)] in 30mL [DMF] was added cesium carbonate (8.7g, 26. [7MMOL)] followed by benzyl 3-bromopropyl ether (7.7g, 33.6mmol). The solution was stirred at 45 [XB0;C] for 24hr, cooled and poured over water. Extraction with AcOEt followed by washing the extracts with water, drying over anhydrous [NA2SO4] and concentrating under reduced pressure gave the crude residue. Purification over silica gel using AcOEt/hexanes furnished the desired alkylated derivative (8.25g). This product was taken up in [MEOH] (75mL) and hydrogenated over 10percent [PD/C] at 40psi to provide methyl [2- (4- (3-HYDROXYPROPOXY)] phenoxy) -2-methylbutanoate (6.23g, quantitative). [‘H-NMR] [(400MHZ,] [CDC13)] : [8] 6.82 (d, 2H, J=9.4Hz), 6.78 (d, 2H, J=9.2Hz), 4.08 (t, 2H, J=6. [1HZ),] 3.87 (t, 2H, J=6Hz), 3.79 (s, 3H), 2.06-1. 92 (m, 4H), 1.44 (s, 3H), 0.99 (t, 3H, J=7.4Hz).
According to the analysis of related databases, 54314-84-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK & CO., INC.; WO2004/10992; (2004); A1;,
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