Application of 25245-34-5,Some common heterocyclic compound, 25245-34-5, name is 2-Bromo-1,4-dimethoxybenzene, molecular formula is C8H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-Bromo-1,4-dimethoxybenzene 39a (250 mg, 1.15 mmol), 2-formylphenylboronic acid 34 (207 mg, 1.38 mmol), tetrakis(triphenylphosphine)palladium(0) (133 mg, 0.29 mmol) and CsF (437 mg, 2.88 mmol) were added to a microwave vial in dimethoxyethane (2 mL) as solvent and the solution was degassed for 2 min. The reaction mixture was transferred to a microwave reactor at 150 C and 150 W power with vigorous stirring for 30 min. On completion, the reaction mass was filtered off, adsorbed on silica and subjected to column chromatography (5% EtOAc/Hexane) to yield the product 40a as white low melting solid (246 mg, 1.02 mmol, 88%). 1H NMR (500 MHz, CDCl3) d 9.79 (1H, s, CHO), 8.01-7.97 (1H, m, ArH), 7.64 (1H, td, J = 7.5, 1.2 Hz, ArH), 7.48 (1H, t, J = 7.6 Hz, ArH), 7.38-7.34 (1H, m, ArH), 6.94 (1H, dd, J = 8.9, 3.0 Hz, ArH), 6.90 (1H, d, J = 8.9 Hz, ArH), 6.87 (1H, d, J = 3.0 Hz, ArH), 3.81 (3H, s, OMe), 3.67 (3H, s, OMe); 13C NMR (126 MHz, CDCl3) d 192.5, 153.8, 150.7, 141.6, 134.0, 133.7, 131.0, 127.8, 127.7, 126.6, 117.3, 114.4, 111.8, 55.9, 55.8.
The synthetic route of 25245-34-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Pradeep, Priyamvada; Ngwira, Kennedy J.; Reynolds, Chevonne; Rousseau, Amanda L.; Lemmerer, Andreas; Fernandes, Manuel A.; Johnson, Myron M.; de Koning, Charles B.; Tetrahedron; vol. 72; 51; (2016); p. 8417 – 8427;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem