Electric Literature of 1836-62-0, These common heterocyclic compound, 1836-62-0, name is 2-(2-Methoxyphenoxy)ethylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 1 : Preparation of carvedilol phosphate 4-(Oxiranylmethoxy)-9H-carbazole (75 gm) was added to 2-(2- methoxyphenoxy)ethylamine (140 gm) at room temperature, followed by stirring the reaction mixture for 37 hours at room temperature. Ethyl acetate (385 ml) was added to the reaction mass, followed by maintaining the resulting mass at room temperature for 1 hour 30 minutes. The resulting mass was cooled to 0 to 5C and then maintained at the same temperature for 1 hour 30 minutes. The separated solid was filtered, washed with chilled ethyl acetate and then dried to obtain carvedilol. To the carvedilol obtained was added acetone (300 ml) and water (100 ml) at room temperature. To the reaction mixture was added phosphoric acid (5 ml), followed by stirring the reaction mixture at room temperature. The separated solid was filtered and then dried to obtain 90 gm of carvedilol phosphate.
The synthetic route of 1836-62-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; SUBASH CHANDER REDDY, Kesireddy; VAMSI KRISHNA, Bandi; WO2014/108921; (2014); A2;,
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