Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 701-07-5, name is 2-(2′-Bromophenoxy)propane, A new synthetic method of this compound is introduced below., Product Details of 701-07-5
An Et2O solution (10 mL) of I2 (1.21 g, 4.78 mmol) was added to a solid of 1 (0.72 g,0.79 mmol) to prepare the solution of diiodophenylarsine (2). Without isolation, thesolution of 2 was employed the subsequent reaction. To an Et2O solution (10 mL) of1-bromo-2-isopropoxybenzene (1.6 mL, 9.97 mmol) was added a hexane solution ofn-butyllithium (1.6 M, 6.0 mL, 9.6 mmol) at 0 C under N2 atmosphere, and the reactionmixture was stirred at the ambient temperature for 1 h. To the reaction mixture was thesolution of 2 was added at 0 C. The reaction temperature was raised to the ambienttemperature, and the reaction mixture was stirred for 5 h. The reaction was quenchedby distilled water (20 mL), and the products were extracted with EtOAc. The combinedorganic layers were dried over MgSO4, and volatiles were removed in vacuo. The residuewas subjected to recrystallization from EtOH, and washed with MeOH to obtaincolorless solids of 3c (1.52 g, 3.61 mmol, 72%). 1H NMR (CDCl3, 400 MHz) delta 7.34-7.24 (m,7H), 6.86 (t, J = 8.4 Hz, 2H), 6.83-6.77 (m, 4H), 4.50 (sep, J = 6.0 Hz, 2H), 1.18 (d, J = 6.0Hz, 6H), 1.08 (d, J = 6.4 Hz, 6H) ppm; 13C NMR (CDCl3, 100 MHz) delta 159.6, 139.9, 134.4,129.5, 129.4, 128.2, 127.9, 120.7, 112.1, 70.2, 21.9, 21.7 ppm. HR FAB-MS (m/z):calculated for C24H27O2As [M]+; 422.1227, observed; 422.1211.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Imoto, Hiroaki; Yamazawa, Chieko; Tanaka, Susumu; Kato, Takuji; Naka, Kensuke; Chemistry Letters; vol. 46; 6; (2017); p. 821 – 823;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem