In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 645-36-3 as follows. Recommanded Product: 2,2-Diethoxyethanamine
[00231] To a solution of cyanogen bromide (25 g, 236.03 mmol) in hexane (80 mL) was added a solution of the amino-acetaldehyde diethyl acetal (34.3 mL, 236.03 mmol) in diethyl ether (80 mL) at room temperature. The resulting mixture was stuffed overnight. A white solid was formed and was removed by filtration and washed with diethyl ether. The filtrate was concentrated and purified by flash chromatography on silica gel (eluted with 0/100 to 5/95 methanol/dichloromethane) to afford N- (2,2-diethyloxyethyl)carbodiimide (27 g, 72% yield) as a bright yellow oil. Rt (retention time) = 1.82 mm; MS m/z: 159.20 [M+1].
According to the analysis of related databases, 645-36-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; CHOI, Hwan, Geun; LIANG, Yanke; GRAY, Nathanael; (135 pag.)WO2016/14542; (2016); A1;,
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