Application of 6298-96-0,Some common heterocyclic compound, 6298-96-0, name is 1-(4-Methoxyphenyl)ethylamine, molecular formula is C9H13NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 5-ethoxy-4-chlorothieno[2,3-d]pyrimidine (163 mg, 0.76 mmol) and (S)-1-(4-methoxyphenyl)ethylamine (120 mg, 0.79 mmol) and triethylamine (159 muL, 1.14 mmol) in DMF (2.0 mL) was allowed to react for 5 hours at 50 C. The reaction mixture was filtered through a cotton plug and purified by High Pressure Liquid Chromatography (HPLC) (Gilson system; Phenomenex column: Luna 5mu C18(2), 150¡Á21.20 mm, 5mu micro) with a water/acetonitrile gradient. Appropriate fractions were pooled to provide 125 mg of pale yellow solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(4-Methoxyphenyl)ethylamine, its application will become more common.
Reference:
Patent; Brewster, William Kirkland; Klittich, Carla Jean Rasmussen; Balko, Terry William; Breaux, Nneka Tuere; Erickson, William Randal; Hunter, James Edward; Lowe, Christian Thomas; Ricks, Michael John; Siddall, Thomas Lyman; Yerkes, Carla Nanette; Zhu, Yuanming; US2006/89370; (2006); A1;,
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