Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 33170-72-8, name is 2-Bromo-1,1-dimethoxypropane, A new synthetic method of this compound is introduced below., Computed Properties of C5H11BrO2
(Cis) -2- [4- [3- (2H-1,2,3-triazol-2-yl) phenylamino](Amino) -5- (carbamoyl) pyrimidin-2-ylamino] cyclohexylcarbamate (1.0 g, 2 mmol) was dissolved in 20 mL DMF,2-Bromo-1,1-dimethoxypropane (1.8 g, 10 mmol) was added and the reaction was carried out at 60 C for 48 h.After adding ice-water, the mixture was extracted with ethyl acetate,Dried, concentrated and separated by silica gel column (methanol: methylene chloride = 1: 10) to give 110 mg of the product in 10% yield.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; KBP Biosciences Co., Ltd.; Wang, Aichen; Qian, Linyi; (29 pag.)CN104640863; (2016); B;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem