Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 36865-41-5, name is 1-Bromo-3-methoxypropane, A new synthetic method of this compound is introduced below., SDS of cas: 36865-41-5
Step 1: Preparation of 4-bromo-l-ehloro-2- 3-methoxypropoxy)benzene A 250 mL round-bottomed flask was charged with 5-bromo-2-chloro-phenol (22 g, 106 mmol), 1 -bromo-3-methoxy-propane ( 19.5 g, 127 mmol), 2CO3 (30 g, 212 mmol) and DMF (50 mL). The resultant mixture was stirred at 50 C for 3 hours, then ethyl acetate and water were added. The organic phase was separated, and then dried over anhydrous a SO-i and then concentrated to give 4-bromo-l -chloro-2-(3-methoxypropoxy)benzene (30 g).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HAN, Xingchun; JAVANBAKHT, Hassan; JIANG, Min; LIANG, Chungen; WANG, Jianping; WANG, Yongguang; WANG, Zhanguo; WEIKERT, Robert James; YANG, Song; ZHOU, Chengang; WO2015/113990; (2015); A1;,
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