Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 109-85-3, name is 2-Methoxyethylamine, A new synthetic method of this compound is introduced below., SDS of cas: 109-85-3
4-Amino-N-hydroxy-1,2,5-oxadiazole-3-carbimidoyl chloride (2.13 kg, 13.15 mol) was mixed with EtOAc(13 L). At 0-5C, 2-methoxyethylamine (1.1 kg, 14.46 mol) was added in one portionwhile stirring. The reaction temperature rose to 41C. The reaction was cooled to 0-5C. TEA (2.0kg, 19.73 mol) was added. After stirring 5 mm, the reaction was washed with water (5 L), brine (5 L),dried over sodium sulfate, and concentrated to give the desired product (1.61 kg, 61%) as a brownoil. LCMS (M+H): m/z = 202.1. 1H NMR (400MHz, DMSO-d6): 6 10.65 (s, 1H), 6.27 (s, 2H), 6.10 (t, J = 6.5Hz, 1H), 3.50 (m, 2H), 3.35 (d, J = 5. 8Hz, 2H), 3.08 (s, 3H).
The synthetic route of 109-85-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; KAZMIERSKI, Wieslaw Mieczyslaw; DE LA ROSA, Martha; SAMANO, Vincent; (70 pag.)WO2017/2078; (2017); A1;,
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